F1000Research
F1000Research
5 years ago

Recent advances in managing gastrointestinal stromal tumor [version 1; referees: 2 approved]

Florence Duffaud, Axel Le Cesne
Constitutive activating mutations in KIT and platelet-derived growth factor receptor α (PDGFRα) are heavily involved in the pathobiology of gastrointestinal stromal tumors (GISTs). This disease has served as an effective “proof-of-concept” model for targeting gain-of-function kinase mutations in cancer. This review discusses the current standard of care in terms of pharmacotherapy in the management of localized and metastatic GISTs.

Publisher URL: https://f1000research.com/articles/6-1689/v1

DOI: 10.12688/f1000research.11118.1

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