5 years ago

Poly-cytosine DNA as a High-Affinity Ligand for Inorganic Nanomaterials

Poly-cytosine DNA as a High-Affinity Ligand for Inorganic Nanomaterials
Chang Lu, Biwu Liu, Yibo Liu, Zhicheng Huang, Yibin Ying, Juewen Liu
Attaching DNA to nanomaterials is the basis for DNA-directed assembly, sensing, and drug delivery using such hybrid materials. Poly-cytosine (poly-C) DNA is a high affinity ligand for four types of commonly used nanomaterials, including nanocarbons (graphene oxide and single-walled carbon nanotubes), transition metal dichalcogenides (MoS2 and WS2), metal oxides (Fe3O4 and ZnO), and metal nanoparticles (Au and Ag). Compared to other homo-DNA sequences, poly-C DNA has the highest affinity for the first three types of materials. Using a diblock DNA containing a poly-C block to attach to surfaces, the target DNA was successfully hybridized to the other block on graphene oxide more efficiently than that containing a typical poly-A block, especially in the presence of non-specific background DNA, proteins, or surfactants. This work provides a simple solution for functionalizing nanomaterials with non-modified DNA and offers new insights into DNA biointerfaces. Straight-C student: Poly-cytosine (poly-C) DNA adsorbs tighter than other DNA homopolymers (such as poly-A) on nanocarbons, metal oxides, and transition-metal dichalcogenides, allowing poly-C to be used as a general anchor on these surfaces for their functionalization, especially in the presence of competing proteins, nucleic acids, and surfactants. F=fluorophore.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/anie.201702998

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