3 years ago

An Anion−π Interaction Strongly Stabilizes the β-Sheet Protein WW

An Anion−π Interaction Strongly Stabilizes the β-Sheet Protein WW
Natalie A. Bécar, Kimberlee S. Larsen, Wendy M. Billings, Joshua L. Price, Eliza E. K. Lawrence, Mason S. Smith
Anions have long been known to engage in stabilizing interactions with electron-deficient arenes. However, the precise nature and energetic contribution of anion−π interactions to protein stability remains a subject of debate. Here, we show that placing a negatively charged Asp in close proximity to electron-rich Phe in a reverse turn within the WW domain results in a favorable interaction that increases WW conformational stability by −1.3 kcal/mol.

Publisher URL: http://dx.doi.org/10.1021/acschembio.7b00768

DOI: 10.1021/acschembio.7b00768

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