4 years ago

Probing Biomolecular Interactions with Gold Nanoparticle-Decorated Single-Walled Carbon Nanotubes

Probing Biomolecular Interactions with Gold Nanoparticle-Decorated Single-Walled Carbon Nanotubes
Dan C. Sorescu, Seth C. Burkert, Raymond W. Euler, Alexander Star, Wenting Shao, Zachary P. Michael
Hybrid nanomaterials comprising metal–graphitic interfaces are uniquely suitable to probe molecular interactions and the associated phenomena such as charge transfer and adsorbate spillover effects. Herein, we study the modulation of the electronic and chemical properties of gold nanoparticle-decorated single-walled carbon nanotubes (SWCNT) using Raman spectroscopy and measurements of field-effect transistor (FET) characteristics. SWCNT are extremely sensitive to changes in the local electronic environment and therefore gold-analyte interactions may be probed both through changes in FET characteristics (as an electrical transducer) and in surface-enhanced Raman scattering (as a chromophore). We study these changes both experimentally and theoretically in order to elucidate the electronic structure of complex nanocomposites, and the information gathered from these experiments is applied to the study of biomolecular interactions with gold nanoparticle-decorated SWCNT. This study, in addition to providing deeper understanding of metal–graphitic interfaces, will offer a combined approach to SWCNT biosensing methodology based on the dual monitoring of the FET–Raman characteristics, which we demonstrate through detection of glutathione.

Publisher URL: http://dx.doi.org/10.1021/acs.jpcc.7b06056

DOI: 10.1021/acs.jpcc.7b06056

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