Angewandte Chemie - International Edition
Angewandte Chemie - International Edition
5 years ago

Non-Pincer-Type Manganese Complexes as Efficient Catalysts for the Hydrogenation of Esters

Non-Pincer-Type Manganese Complexes as Efficient Catalysts for the Hydrogenation of Esters
Evgeny A. Uslamin, Marcel Garbe, Martin Lutz, Emiel J. M. Hensen, Evgeny A. Pidko, Matthias Beller, Robbert van Putten, Laurent Lefort, Kathrin Junge, Angela Gonzalez-de-Castro, Chong Liu
Catalytic hydrogenation of carboxylic acid esters is essential for the green production of pharmaceuticals, fragrances, and fine chemicals. Herein, we report the efficient hydrogenation of esters with manganese catalysts based on simple bidentate aminophosphine ligands. Monoligated Mn PN complexes are particularly active for the conversion of esters into the corresponding alcohols at Mn concentrations as low as 0.2 mol % in the presence of sub-stoichiometric amounts of KOtBu base. It's SuperMn! A bidentate MnI P,N complex is a highly active catalyst for the hydrogenation of esters under mild conditions. Quantitative yields of alcohols are obtained for a variety of aliphatic and aromatic esters, while showing complete chemoselectivity for ester reduction in the presence of internal and terminal alkene functionalities.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/anie.201701365

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