Chemical Reviews
Chemical Reviews
5 years ago

Exploring the Boundaries of “Practical”: De Novo Syntheses of Complex Natural Product-Based Drug Candidates

Exploring the Boundaries of “Practical”: De Novo Syntheses of Complex Natural Product-Based Drug Candidates
Francesco Manoni, Tyler K. Allred, Patrick G. Harran
This review examines the state of the art in synthesis as it relates to the building of complex architectures on scales sufficient to drive human drug trials. We focus on the relatively few instances in which a natural-product-based development candidate has been manufactured de novo, rather than semisynthetically. This summary provides a view of the strengths and weaknesses of current technologies, provides perspective on what one might consider a practical contribution, and hints at directions the field might take in the future.

Publisher URL: http://dx.doi.org/10.1021/acs.chemrev.7b00126

DOI: 10.1021/acs.chemrev.7b00126

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