3 years ago

α-Imino Esters in Organic Synthesis: Recent Advances

α-Imino Esters in Organic Synthesis: Recent Advances
Maryam Zirak, Bagher Eftekhari-Sis
α-Imino esters are useful precursors for the synthesis of a variety of types of natural and unnatural α-amino acid derivatives, with a wide range of biological activities. Due to the adjacent ester group, α-imino esters are more reactive relative to other types of imines and undergo different kinds of reactions, including organometallics addition, metal catalyzed vinylation and alkynylation, aza-Henry, aza-Morita-Baylis-Hillman, imino-ene, Mannich-type, and cycloaddition reactions, as well as hydrogenation and reduction. This review discusses the mechanism, scope, and applications of the reactions of α-imino esters and related compounds in organic synthesis, covering the literature from the last 12 years.

Publisher URL: http://dx.doi.org/10.1021/acs.chemrev.7b00064

DOI: 10.1021/acs.chemrev.7b00064

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