Journal of Organic Chemistry
Journal of Organic Chemistry
5 years ago

Oxidation of Secondary Methyl Ethers to Ketones

Oxidation of Secondary Methyl Ethers to Ketones
Floris P. J. T. Rutjes, Pieter J. Gilissen, Daniel Blanco-Ania
We present a mild way of converting secondary methyl ethers into ketones using calcium hypochlorite in aqueous acetonitrile with acetic acid as activator. The reaction is compatible with various oxygen- and nitrogen-containing functional groups and afforded the corresponding ketones in up to 98% yield. The use of this methodology could expand the application of the methyl group as a useful protecting group.

Publisher URL: http://dx.doi.org/10.1021/acs.joc.7b00632

DOI: 10.1021/acs.joc.7b00632

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