3 years ago

Atom-Economic Route to Cyanoarenes and 2,2′-Dicyanobiarenes via Iron-Catalyzed Chemoselective [2 + 2 + 2] Cycloaddition Reactions of Diynes and Tetraynes with Alkynylnitriles

Atom-Economic Route to Cyanoarenes and 2,2′-Dicyanobiarenes via Iron-Catalyzed Chemoselective [2 + 2 + 2] Cycloaddition Reactions of Diynes and Tetraynes with Alkynylnitriles
Avijit Goswami, Hrishikesh Chowdhury, Divya Bhatt
An efficient protocol for the synthesis of cyanoarenes has been developed via an iron-catalyzed chemoselective [2 + 2 + 2] cycloaddition reaction of diynes with alkynylnitriles under mild reaction conditions with good to excellent yields. The reaction is catalyzed by the combination of FeCl2·4H2O as a metal source, 2-(2,6-diisopropylphenyl)iminomethylpyridine (dipimp) as a ligand, and Zn as a reducing agent in DME solvent. The protocol was further extended to the synthesis of 2,2′-dicyanobiarene skeletons from the reaction of tetraynes with alkynylnitriles.

Publisher URL: http://dx.doi.org/10.1021/acs.orglett.7b01217

DOI: 10.1021/acs.orglett.7b01217

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