Bioorganic and Medicinal Chemistry
Bioorganic and Medicinal Chemistry
5 years ago

Synthesis and structure-activity relationship of teixobactin analogues via convergent Ser ligation

Synthesis and structure-activity relationship of teixobactin analogues via convergent Ser ligation
Convergent Ser/Thr ligation has been used to prepare a series of teixobactin analogues (28 in total) to establish a structure-activity relationship of teixobactin. anti-bacterial evaluations of these synthetic analogues have revealed the critical amino acid residues and the sites tolerable of modifications. These studies will shed lights on the further development of teixobactin analogues with improved antibacterial activities.

Publisher URL: www.sciencedirect.com/science

DOI: S0968089617305874

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