5 years ago

Ca2+ Induced Crosslinking of AIE-Active Polyarylene Ether Nitrile into Fluorescent Polymeric Nanoparticles for Cellular Bioimaging

Ca2+ Induced Crosslinking of AIE-Active Polyarylene Ether Nitrile into Fluorescent Polymeric Nanoparticles for Cellular Bioimaging
Lianhui Wang, Xiaobo Liu, Chunhui Wu, Xiaotian Guan, Pan Wang, Kun Jia, Yuan Tian, Xuefei Zhou
Biocompatible fluorescent polymeric nanoparticles (FPNs) are promising luminescent probes in cellular bioimaging, while the fabrication of high-quantum-yield FPN using nonconjugated heterochain polymers derived from step-growth polymerization is still in its infancy. Herein, the nonconjugated polyarylene ether nitrile (PEN) is endowed with aggregation-induced emission (AIE) feature by incorporation of an AIEgen named of 1,2-di(4-hydroxyphenyl)-1,2-diphenylethene into macromolecular backbone. Furthermore, the AIE-active PEN is crosslinked into water soluble fluorescent nanospheres showing good biocompatibility and strong emission ≈480 nm with a quantum yield of 21% in the presence of Ca2+, which allows the successful bioimaging of cancer cells. Due to the facile fabrication of FPNs and their effective bioimaging performance, the current work will open the way for the biomedical applications of various high performance polyarylene ethers. Polyarylene ether nitrile (PEN) showing aggregation-induced emission (AIE) feature is synthesized by introducing AIEgen of (1,2-di(4-hydroxyphenyl)-1,2-diphenylethene into macromolecular backbone. The AIE-active PEN can be further crosslinked with Ca2+ into fluorescent polymeric nanoparticles, which exhibit good biocompatibility and can be employed as a fluorescent probe for cancer cellular bioimaging.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/marc.201700360

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.