5 years ago

Fluoride concentration and amount of dentifrice influence enamel demineralization in situ

This study evaluated the effect of conventional (CD, 1100ppm F) and low-fluoride (LFD, 550ppm F) dentifrices, applied in different quantities, on enamel demineralization, and on fluoride (F) concentrations in the dental biofilm formed in situ. Methods Five combinations of dentifrices and quantities were tested: placebo (P–F-free) applied on all brush bristles; LFD applied by the transversal technique (0.3g–T1) or on all bristles (0.6g–T2); and CD applied in a pea-sized amount (0.15g–T3) or by the transversal technique (0.3g–T4), in order to produce comparable intensities (F concentration in the dentifrice×amount applied to the brush). Volunteers (n=13, 20–36 years old) wore palatal devices containing 4 bovine enamel blocks, and performed cariogenic challenges (30% sucrose solution) 6×/day, and brushing 3×/day, following a double-blind, cross-over and randomized protocol. On the 8th day, biofilm was collected 5 and 60min after brushing. The percentage of surface hardness loss (%SH), integrated loss of subsurface hardness (ΔKHN) and biofilm F concentrations (solid and fluid phases) were determined. Data were analyzed by repeated-measures ANOVA, Student-Newman-Keuls test, and Pearson’s correlation coefficient (p<0.05). Results Significantly lower ΔKHN was observed for treatments with higher intensity (T2 and T4) in comparison with the lower intensity (T1 and T3). A strong correlation was observed between ΔKHN and F concentrations in total biofilm (r=−0.71) and biofilm fluid (r=−0.72) 5min after brushing. Conclusions The treatment intensity has a significant influence on the development of caries lesions in situ. Clinical significance: The intensity of treatment (amount of dentifrice×concentration) used during brushing is a more relevant parameter of the clinical efficacy of the product than just the evaluation of the F concentration. It was observed that the use of small amounts of CD significantly reduced Protective effects against dental caries.

Publisher URL: www.sciencedirect.com/science

DOI: S030057121730218X

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