3 years ago

CuI/Oxalic Diamide-Catalyzed Cross-Coupling of Thiols with Aryl Bromides and Chlorides

CuI/Oxalic Diamide-Catalyzed Cross-Coupling of Thiols with Aryl Bromides and Chlorides
Chin-Fa Lee, Bo-Hao Shih, Kai Du, Daggula Mallikarjuna Reddy, Yung-Jing Xue, Yi-Ling Chen, Chao-En Li, Chia-Wei Chen
A practical synthetic method for the synthesis of diversified thioethers using oxalic diamides as highly air-stable ligands through copper catalysis is demonstrated. A variety of aryl and alkyl thiols were successfully coupled with aryl bromides and aryl chlorides to afford the corresponding thioethers in good yields. This work is the first copper-catalyzed thioetherification of unactivated aryl chlorides. More information can be found in the Full Paper by C.-F. Lee et al. (DOI: 10.1002/chem.201701671).

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/chem.201702327

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