3 years ago

Inside Back Cover: Cobalt-Porphyrin-Catalysed Intramolecular Ring-Closing C−H Amination of Aliphatic Azides: A Nitrene-Radical Approach to Saturated Heterocycles (Chem. Eur. J. 33/2017)

Inside Back Cover: Cobalt-Porphyrin-Catalysed Intramolecular Ring-Closing C−H Amination of Aliphatic Azides: A Nitrene-Radical Approach to Saturated Heterocycles (Chem. Eur. J. 33/2017)
Bas de Bruin, Petrus F. Kuijpers, Willem B. Breukelaar, Nicolaas P. van Leest, Martijn J. Tiekink, Joost N. H. Reek, Jarl Ivar van der Vlugt, Daniël L. J. Broere
A snake bites its own tail in the cobalt-catalysed activation of aliphatic azides, enabling the direct synthesis of several N-heterocycles from aliphatic azides in good to excellent yields. Detailed mechanistic investigations revealed a metallo-radical intramolecular C−H activation mechanism, and enantioselective radical-type ring-closure C−H amination from aliphatic azides proved possible. More information can be found in the Full Paper by B. de Bruin et al. on page 7945.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/chem.201701400

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