Chemistry - A European Journal
Chemistry - A European Journal
5 years ago

Highly Selective Olefin-Assisted PdII-Catalyzed Oxidative Alkynylation of Enallenes

Highly Selective Olefin-Assisted PdII-Catalyzed Oxidative Alkynylation of Enallenes
Jan-E. Bäckvall, Youai Qiu, Bin Yang, Jeffrey L. Henry, Daniels Posevins
An olefin-assisted, palladium-catalyzed oxidative alkynylation of enallenes for regio- and stereoselective synthesis of substituted trienynes has been developed. The reaction shows a broad substrate scope and good tolerance for various functional groups on the allene moiety, including carboxylic acid esters, free hydroxyls, imides, and alkyl groups. Also, a wide range of terminal alkynes with electron-donating and electron-withdrawing aryls, heteroaryls, alkyls, trimethylsilyl, and free hydroxyl groups are tolerated. Highly selective palladium-catalyzed oxidative alkynylation of enallenes has been developed, affording regio- and stereoselectively substituted trienynes. The reaction shows a broad substrate scope with good tolerance for various functional groups on the enallene and the terminal alkyne.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/chem.201701654

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.