5 years ago

Galactomannan from Antrodia cinnamomea Enhances the Phagocytic Activity of Macrophages

Galactomannan from Antrodia cinnamomea Enhances the Phagocytic Activity of Macrophages
Jung-Feng Hsieh, Yueh-Tung Lu, Yi-Ting Tsai, Kuo-Feng Hua, Shih-Hsiung Wu, Lan-Hui Li, Ching-Ming Chang, Feng-Ling Yang, Shih-Hao Zhan, Namal Perera
Galactomannan with an octasaccharide-repeating unit (ACP) was isolated from Taiwan medicinal mushroom Antrodia cinnamomea, and its chemical structure was determined herein. ACP significantly enhanced the phagocytosis and bactericidal activity of J774A.1 murine macrophages against Escherichia coli, with prospects for developing a new immunomodulatory compound or adjuvant in immunotherapy and vaccination.

Publisher URL: http://dx.doi.org/10.1021/acs.orglett.7b01468

DOI: 10.1021/acs.orglett.7b01468

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