Journal of Organic Chemistry
Journal of Organic Chemistry
5 years ago

Organocatalytic Direct N-Acylation of Amides with Aldehydes under Oxidative Conditions

Organocatalytic Direct N-Acylation of Amides with Aldehydes under Oxidative Conditions
Cheng Ma, Xiang Liu, Chenguang Zheng
The direct oxidative N-acylation reaction of primary amides with aryl/α,β-unsaturated aldehydes was achieved in the presence of azolium salt C3 and an inorganic base using 3,3′,5,5′-tetra-tert-butyldiphenoquinone as the oxidant, thus providing an efficient approach for the synthesis of three types of imide compounds including N-sulfonylcarboxamides, N-sulfinylcarboxamides, and dicarboxyimides in good yield.

Publisher URL: http://dx.doi.org/10.1021/acs.joc.7b00457

DOI: 10.1021/acs.joc.7b00457

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