Organic Letters
Organic Letters
5 years ago

Copper-Catalyzed Sulfonyl Azide–Alkyne Cycloaddition Reactions: Simultaneous Generation and Trapping of Copper–Triazoles and −Ketenimines for the Synthesis of Triazolopyrimidines

Copper-Catalyzed Sulfonyl Azide–Alkyne Cycloaddition Reactions: Simultaneous Generation and Trapping of Copper–Triazoles and −Ketenimines for the Synthesis of Triazolopyrimidines
Kayambu Namitharan, Madhu Nallagangula
First simultaneous generation and utilization of both copper–triazole and −ketenimine intermediates in copper-catalyzed sulfonyl azide–alkyne cycloaddition reactions is achieved for the one-pot synthesis of triazolopyrimidines via a novel copper-catalyzed multicomponent cascade of sulfonyl azides, alkynes, and azirines. Significantly, the reaction proceeds under very mild conditions in good yields.

Publisher URL: http://dx.doi.org/10.1021/acs.orglett.7b01500

DOI: 10.1021/acs.orglett.7b01500

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