5 years ago

Photoredox-Catalyzed Hydroacylation of Olefins Employing Carboxylic Acids and Hydrosilanes

Photoredox-Catalyzed Hydroacylation of Olefins Employing Carboxylic Acids and Hydrosilanes
Weipeng Li, Zhongkai Wu, Nan Li, Shouyun Yu, Rehanguli Ruzi, Muliang Zhang, Chengjian Zhu, Junwei Xi
A hydroacylation reaction of alkenes has been achieved employing readily available carboxylic acids as the acyl source and hydrosilanes as a hydrogen source via photoredox catalysis. The combination of both single electron transfer and hydrogen atom transfer steps has dramatically expanded new applications of carboxylic acids in organic synthesis. The protocol also features extremely mild conditions, broad substrate scope, and good functional group tolerance, affording a novel and convenient approach to hydroacylation of alkenes.

Publisher URL: http://dx.doi.org/10.1021/acs.orglett.7b01391

DOI: 10.1021/acs.orglett.7b01391

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