5 years ago

Ruthenium(II)-Catalyzed C−C Arylations and Alkylations: Decarbamoylative C−C Functionalizations

Ruthenium(II)-Catalyzed C−C Arylations and Alkylations: Decarbamoylative C−C Functionalizations
Marc Moselage, Frederik Kramm, Lutz Ackermann, Jie Li
Ruthenium(II)biscarboxylate catalysis enabled selective C−C functionalizations by means of decarbamoylative C−C arylations. The versatility of the ruthenium(II) catalysis was reflected by widely applicable C−C arylations and C−C alkylations of aryl amides, as well as acids with modifiable pyrazoles, through facile organometallic C−C activation. Amid the methods: Amide σ-C−C arylations were accomplished by versatile ruthenium(II) carboxylate decarbamoylative catalysis, which enabled decarboxylative ipso C−C alkylations by facile organometallic C−C cleavage. The method is versatile, robust, and mild, and mechanistic insights are discussed.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/anie.201701231

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