4 years ago

Total Synthesis of Biselyngbyaside

Total Synthesis of Biselyngbyaside
Yurika Tanabe, Akifumi Ohkubo, Kiyotake Suenaga, Eisuke Sato, Miho Sato, Naoya Nakajima
The first total synthesis of biselyngbyaside, an 18-membered macrolide glycoside, was achieved. The glycoside bond was introduced using the Schmidt method before construction of the 18-membered ring due to the instability of the conjugated diene and the β-hydroxy ester moiety. The macrolactone ring was constructed using the Mitsunobu reaction followed by intramolecular the Stille coupling reaction.

Publisher URL: http://dx.doi.org/10.1021/acs.joc.7b00905

DOI: 10.1021/acs.joc.7b00905

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