3 years ago

Characterization of antigenic relatedness between GII.4 and GII.17 noroviruses using serum samples from norovirus-infected patients.

Zhuang YL, Qin L, Dai YC, Huang Q, Xia M, Jiang X, Zhang XF, Long Y, Tan M, Li JD
A novel GII.17 norovirus variant caused major gastroenteritis epidemics in China in 2014 -2016. To explore the host immune factors in selection of the emergence of this new variant, we characterized its antigenic relatedness with the GII.4 noroviruses that have dominated in China for decades. Through ELISA and histo-blood group antigen (HBGA) blocking assays using sera from GII.4 and the GII.17 variant-infected patients, respectively, we observed limited cross immune reactivity by the ELISA but little reactivity by the HBGA blocking assay between GII.4 norovirus and the new GII.17 variant. Our data suggest that, among other possible factors, the GII.4 specific herd immunity had little role in the emergence of the new GII.17 variant. Thus, GII.17 may be an important active antigenic or immunotype that needs to be considered for future vaccine strategies against human noroviruses.

Publisher URL: https://www.ncbi.nlm.nih.gov/pubmed/28904188

DOI: PubMed:28904188

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