3 years ago

Copper-Mediated Decarboxylative Coupling of Benzamides with ortho-Nitrobenzoic Acids by Directed C−H Cleavage

Copper-Mediated Decarboxylative Coupling of Benzamides with ortho-Nitrobenzoic Acids by Directed C−H Cleavage
Masahiro Miura, Kazutaka Takamatsu, Koji Hirano
A copper-mediated decarboxylative coupling of benzamides with ortho-nitrobenzoic acids by 8-aminoquinoline-directed C−H cleavage has been developed. This reaction proceeds smoothly with only a copper salt to produce the corresponding biaryl compounds in good yields. The products can be easily transformed into various nitrogen-containing heterocyclic compounds. Moreover, the combination of copper and a suitable base promotes a decarboxylative C−H arylation and cyclization sequence to deliver phenanthridinone derivatives in one pot. On Q: A copper-mediated decarboxylative coupling of benzamides with ortho-nitrobenzoic acids by a directed C−H cleavage proceeds to deliver the corresponding biaryls in good yields. The products can be readily transformed into various nitrogen-containing heterocycles. Additionally, a decarboxylative C−H arylation and cyclization sequence occurs, by adding a suitable base, to produce phenanthridinone derivatives in one pot.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/anie.201701918

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