5 years ago

Immunocontraception: Filamentous Bacteriophage as a Platform for Vaccine Development.

Samoylov TI, Bartol FF, Braden TD, Spencer JA
Population control of domestic, wild and invasive species of animals is a global issue of importance to public health, animal welfare and the economy. Although many methods for regulation of animal reproduction are available, the need for effective, safe, and inexpensive contraceptives remains. Immunocontraceptives (contraceptive vaccines) are designed to stimulate the immune system in order to block critical events in the reproductive process and suppress fertility. Platforms used for vaccine development play a critical role in vaccine efficacy, safety, and practicality. One nontraditional platform used for development of contraceptive vaccines is based on filamentous bacteriophages (shortened phages). Filamentous phages comprise a group of rod-shaped bacterial viruses. The core of the virion is a DNA molecule, which is surrounded by phage coat proteins. Phages can be engineered to display fusion (non-phage) peptides as a part of their coat proteins. Such modifications can be accomplished via genetic manipulations of phage DNA or by chemical conjugation of synthetic peptides to phage surface proteins. Phage fusions with antigenic determinants induce humoral as well as cell-mediated immune responses in animals, making them attractive vaccine carriers. Additional advantages of the phage platform include environmental stability, low cost, and safety of phage-based preparations for immunized animals and those administering the vaccines.

Publisher URL: https://www.ncbi.nlm.nih.gov/pubmed/28901276

DOI: PubMed:28901276

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.