Journal of Organic Chemistry
Journal of Organic Chemistry
5 years ago

Ruthenium-Catalyzed Carbonylation of Oxalyl Amide-Protected Benzylamines with Isocyanate as the Carbonyl Source

Ruthenium-Catalyzed Carbonylation of Oxalyl Amide-Protected Benzylamines with Isocyanate as the Carbonyl Source
Ning Wang, Jian Han, Da-Qing Shi, Yingsheng Zhao, Zhi-Bin Huang
An efficient synthesis of isoindolin-1-ones from oxalyl amide-protected benzylamines, through ruthenium-catalyzed intramolecular C(sp2)-H carbonylation, has been developed. Variously substituted benzylamines could be well tolerated in this new protocol, affording the corresponding products in moderate to excellent yields. This approach constitutes the first example of Ru(II)-catalyzed C(sp2)-H carbonylation with isocyanate as a novel commercially available carbonyl source.

Publisher URL: http://dx.doi.org/10.1021/acs.joc.7b00975

DOI: 10.1021/acs.joc.7b00975

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