3 years ago

Palladium Catalyzed Arylation and Benzylation of Nitroarenes Using Aryl Sulfonates and Benzyl Acetates

Palladium Catalyzed Arylation and Benzylation of Nitroarenes Using Aryl Sulfonates and Benzyl Acetates
Ryan Daley, Yodit Aschenaki, Abigail Schnaith, Stephen Davick, Dipannita Kalyani, Rylee Wander, Zubaoyi Yi
Pd-catalyzed arylation or benzylation of nitroazoles using aryl sulfonates or benzyl acetates is described. Electronically varied aryl tosylates and mesylates, as well as benzyl acetates, afford the arylated and benzylated products. Arylation of nitrobenzene is also reported. The relative rate for the arylation of halides is greater than that of tosylates using the reported reaction parameters. These studies enhance the scope of electrophiles for nitroarene arylations and benzylations, which was hitherto limited to the use of halide electrophiles.

Publisher URL: http://dx.doi.org/10.1021/acs.joc.7b00550

DOI: 10.1021/acs.joc.7b00550

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