Angewandte Chemie - International Edition
Angewandte Chemie - International Edition
5 years ago

Reversible Stabilization of Vesicles: Redox-Responsive Polymer Nanocontainers for Intracellular Delivery

Reversible Stabilization of Vesicles: Redox-Responsive Polymer Nanocontainers for Intracellular Delivery
Volker Gerke, Jürgen Klingauf, Armido Studer, Andrea Ricker, Matthias Tesch, Wilke C. de Vries, David Grill, Bart Jan Ravoo, Harald Nüsse
Redox-responsive nanocontainers are prepared by the supramolecular assembly of a responsive polymer shell around a cyclodextrin vesicle core. In their Communication http://doi.org/10.1002/anie.201702620, A. Studer, V. Gerke, B. J. Ravoo, and co-workers demonstrate that vesicles stabilized with a disulfide crosslinked polymer shell can encapsulate functional payloads and release them on encountering a reductive trigger. Cell experiments visualize the release of the toxin phalloidin inside the reducing intracellular micro-environment and its binding to actin filaments.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/anie.201705754

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