5 years ago

One pot synthesis of α,β-epoxy ketones by oxidative coupling of methyl arenes with cinnamic acids involving C(sp3)―H activation and decarboxylative strategy

One pot synthesis of α,β-epoxy ketones by oxidative coupling of methyl arenes with cinnamic acids involving C(sp3)―H activation and decarboxylative strategy
A new one pot oxidative coupling of methyl arenes with cinnamic acids has been developed for the synthesis of α,β-epoxy ketones using MnO2/TBHP combination. The process involves a co-existing C(sp3)―H activation and decarboxylation under aqueous medium, which makes it practical and attractive.

Publisher URL: www.sciencedirect.com/science

DOI: S0040402017303976

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