Tetrahedron
Tetrahedron
5 years ago

Design and synthesis of a second-generation ligand-tethered calcium indicator for plant cell biology based on the fundamental analyses of the structure and physical property

Design and synthesis of a second-generation ligand-tethered calcium indicator for plant cell biology based on the fundamental analyses of the structure and physical property
Calcium ion (Ca2+) is one of the most important second messengers. However, conventional Ca2+ indicators cannot be applied in plant cells. In previous paper, we developed the first-generation protein-ligand tethered calcium indicator that can be applied for living plant cells. Here, we will report the development of second-generation indicator based on the detailed examination on physical properties of the first-generation to improve the drawbacks. Through the examination, we also found that cell permeability of the probe is strongly affected by their aggregation properties. Our findings will provide new strategy for the design of synthetic indicators.

Publisher URL: www.sciencedirect.com/science

DOI: S0040402017303952

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.