3 years ago

Pharesinosides A-G, acylated glycosidic acid methyl esters derivatized by NH2 silica gel on-column catalyzation from the crude resin glycosides of Pharbitis Semen

Pharesinosides A-G, acylated glycosidic acid methyl esters derivatized by NH2 silica gel on-column catalyzation from the crude resin glycosides of Pharbitis Semen
Application of NH2 silica gel column chromatography using CH2Cl2-MeOH was found to show a satisfactory resolution for separation of the crude resin glycosides of Pharbitis Semen (the seeds of Pharbitis nil), led to the isolation of seven new acylated glycosidic acid methyl esters, Pharesinosides A-G (17), along with four known ones (811). These compounds (111) were considered to be generated via methyl esterification of the carboxyl group in acylated glycosidic acids. Their structures including stereochemistry were elucidated on the basis of a combination of the spectroscopic and chemical methods. All isolates were evaluated for anti-tumor migration activities with human colon cancer cell line HCT-116, and compound 7 exhibited a potent migration inhibitory activity.

Publisher URL: www.sciencedirect.com/science

DOI: S0040402017303083

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