3 years ago

Rh(III)-Catalyzed Carboamination of Propargyl Cycloalkanols with Arylamines via Csp2–H/Csp3–Csp3 Activation

Rh(III)-Catalyzed Carboamination of Propargyl Cycloalkanols with Arylamines via Csp2–H/Csp3–Csp3 Activation
Wei Zeng, Huanfeng Jiang, Huaqiang Zeng, Yong Zhu, Xinwei Hu, Yuanfu Deng, Xun Chen
A Rh(III)-catalyzed carboamination of alkynyl cycloalkanols with arylamines has been developed. This transformation involves a novel Csp2–H/Csp3–Csp3 activation relay and provides an efficient approach to versatile 1,2,3-trisubstituted indoles with a broad range of functional group tolerance.

Publisher URL: http://dx.doi.org/10.1021/acs.orglett.7b01372

DOI: 10.1021/acs.orglett.7b01372

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