3 years ago

Treatment of a mobile intracardiac thrombus using ultra-slow low-dose tissue plasminogen activator in combination with heparin

Treatment of a mobile intracardiac thrombus using ultra-slow low-dose tissue plasminogen activator in combination with heparin
C. B. Polen, P. D. Ratliff, H. N. Mullins Busch
What is known and objective Free-floating thrombi in the right heart occur in a subset of patients with pulmonary embolism with high rates of mortality if untreated. Treatment of choice is controversial and likely patient specific as studies have failed to consistently show a significant difference in mortality between options. Case summary We present a case of a 45-year-old female with a mobile right heart thrombus treated with ultra-slow, low-dose t-PA infusion in combination with heparin. What is new and conclusion Ultra-slow, low-dose infusion of t-PA may be an option for treatment of mobile intracardiac thrombi. Mobile thrombi of the right heart occur in a subset of patients with pulmonary embolism with high rates of mortality if left untreated. Treatment options are varied and likely patient specific with no definitive treatment of choice. We present a case of the successful treatment of a right heart mobile thrombus using an ultra-slow low dose t-PA regimen.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1111/jcpt.12626

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