Bioconjugate Chemistry
Bioconjugate Chemistry
5 years ago

Enhanced and Prolonged Cell-Penetrating Abilities of Arginine-Rich Peptides by Introducing Cyclic α,α-Disubstituted α-Amino Acids with Stapling

Enhanced and Prolonged Cell-Penetrating Abilities of Arginine-Rich Peptides by Introducing Cyclic α,α-Disubstituted α-Amino Acids with Stapling
Makoto Oba, Masakazu Tanaka, Atsushi Ueda, Takuma Kato, Masayuki Kunitake
Cell-penetrating peptides are receiving increasing attention as drug delivery tools, and the search for peptides with high cell-penetrating ability and negligible cytotoxicity has become a critical research topic. Herein, cyclic α,α-disubstituted α-amino acids were introduced into arginine-rich peptides and an additional staple was provided in the side chain. The peptides designed in the present study showed more enhanced and prolonged cell-penetrating abilities than an arginine nonapeptide due to high resistance to protease and conformationally stable helical structures.

Publisher URL: http://dx.doi.org/10.1021/acs.bioconjchem.7b00190

DOI: 10.1021/acs.bioconjchem.7b00190

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