3 years ago
Frontispiece: Bicyclic Peptides as Next-Generation Therapeutics
Dehua Pei, Curran A. Rhodes
Greater conformational rigidity and metabolic stability than linear and monocyclic peptides can be found in bicyclic peptide which are capable of binding to challenging drug targets with antibody-like affinity and specificity. Powerful combinatorial library technologies have recently been developed to rapidly synthesize and screen large bicyclic peptide libraries for ligands against enzymes, receptors, and protein–protein interaction targets. For more details, see the Minireview by D. Pei and C. A. Rhodes on page 12690 ff.
Publisher URL: http://onlinelibrary.wiley.com/resolve/doi
DOI: 10.1002/chem.201785262
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