3 years ago

The role of major virulence factors of AIEC involved in inflammatory bowl disease-a mini-review.

Liao Y, Yang Y, Ma Y, Zhu G, Gong W
Adherent-invasive Escherichia coli (AIEC) has recently attracted more attention because it is closely related to the pathogenicity of human inflammatory bowel disease (IBD). AIEC possesses a multitude of virulence factors. Considering these virulence factors belonging to various virulence groups, including adhesins, invasins, toxins, protectins, and siderophore-mediated iron acquisition, this review summarizes the current knowledge of how the major virulence factors assisting in AIEC survive in, adhere to, and invade host cells. A comprehensive understanding of the interaction of virulence factors with host cells will provide us a new therapeutic strategy for IBD prevention and treatment.

Publisher URL: https://www.ncbi.nlm.nih.gov/pubmed/28918511

DOI: PubMed:28918511

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