4 years ago

Cobalt-catalyzed oxidative esterification of allylic/benzylic C(sp3)–H bonds

Cobalt-catalyzed oxidative esterification of allylic/benzylic C(sp3)–H bonds
A protocol for the cobalt-catalyzed oxidative esterification of allylic/benzylic C(sp3)–H bonds with carboxylic acids was developed in this work. Mechanistic studies revealed that C(sp3)–H bond activation in the hydrocarbon was the turnover-limiting step and the in-situ formed [Co(III)]Ot-Bu did not engage in hydrogen atom abstraction (HAA) of a C–H bond. This protocol was successfully incorporated into a synthetic pathway to β-damascenone that avoided the use of NBS.

Publisher URL: www.sciencedirect.com/science

DOI: S0040402017303654

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