3 years ago

Revealing a Role for NMDA Receptors in Regulating STN Inputs following the Loss of Dopamine

Revealing a Role for NMDA Receptors in Regulating STN Inputs following the Loss of Dopamine
Christopher P. Ford, Aphroditi A. Mamaligas

In this issue of Neuron, Chu et al. (2017) show that dopamine depletion using a 6-OHDA model causes a decrease in hyperdirect inputs from the motor cortex directly to the STN and that rescuing this loss alleviates Parkinsonian symptoms.

Publisher URL: http://www.cell.com/neuron/fulltext/S0896-6273(17)30784-5

DOI: 10.1016/j.neuron.2017.08.041

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