5 years ago

Regioselective TfOH-mediated hydroamidation of ynamides with nitriles

Regioselective TfOH-mediated hydroamidation of ynamides with nitriles
A new TfOH-mediated reaction of ynamides with nitriles as nucleophiles has been developed. The reaction works efficiently under mild reaction conditions to afford a new class of α-acylaminoenamides readily via the intermediacy of keteniminium ion. The reaction displays generality and a broad substrates scope. Additionally, the α-acylaminoenamides could be transformed to highly substituted pyridine, 4-aminopyrimidine or isoquinoline cores.

Publisher URL: www.sciencedirect.com/science

DOI: S0040402017303095

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