Tetrahedron
Tetrahedron
5 years ago

Copper-catalyzed methylation of 1,3-diketones with tert-butyl peroxybenzoate

Copper-catalyzed methylation of 1,3-diketones with tert-butyl peroxybenzoate
Copper-catalyzed radical methylation of 1,3-diketones with tert-butyl peroxybenzoate in air is described, providing a general pathway to α-methyl 1,3-diketones in moderate to good yields. This protocol has been scaled up to 50 g, and one of the synthesized products can be used in the synthesis of medicine, Rosuvastatin.

Publisher URL: www.sciencedirect.com/science

DOI: S0040402017303071

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