Activating or Inhibiting Nrf2?
Activating nuclear factor erythroid 2 (NF-E2)-related factor (Nrf2) is a widely recognized strategy for combating oxidative-stress-induced diseases. However, Nrf2 activation does not always bring advantageous effects. Therefore, before performing Nrf2-targeted therapy, we must pinpoint whether Nrf2 should be activated or inhibited.
Publisher URL: http://www.cell.com/trends/pharmacological-sciences/fulltext/S0165-6147(17)30159-1
DOI: 10.1016/j.tips.2017.08.002
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