3 years ago

Transfer Hydrogenation of Carbonyl Derivatives Catalyzed by an Inexpensive Phosphine-Free Manganese Precatalyst

Transfer Hydrogenation of Carbonyl Derivatives Catalyzed by an Inexpensive Phosphine-Free Manganese Precatalyst
Thierry Roisnel, Antoine Bruneau-Voisine, Vincent Dorcet, Jean-Baptiste Sortais, Christophe Darcel, Ding Wang
A very simple and inexpensive catalytic system based on abundant manganese as transition metal and on an inexpensive phosphine-free bidendate ligand, 2-(aminomethyl)pyridine, has been developed for the reduction of a large variety of carbonyl derivatives with 2-propanol as hydrogen donor. Remarkably, the reaction proceeds at room temperature with low catalyst loading (down to 0.1 mol %) and exhibits a good tolerance toward functional groups. High TON (2000) and TOF (3600 h–1) were obtained.

Publisher URL: http://dx.doi.org/10.1021/acs.orglett.7b01657

DOI: 10.1021/acs.orglett.7b01657

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