5 years ago

Copper-Catalyzed [2 + 2 + 3] Annulation of 1,6-Enynes with α-Bromo-1,3-Dicarbonyl Compounds: Synthesis of Dihydrooxepines

Copper-Catalyzed [2 + 2 + 3] Annulation of 1,6-Enynes with α-Bromo-1,3-Dicarbonyl Compounds: Synthesis of Dihydrooxepines
Yong-Min Liang, Lan Zheng
Copper-catalyzed [2 + 2 + 3] annulation of 1,6-enynes with α-bromo-1,3-dicarbonyl compounds is described. This reaction provides facile access to seven-membered dihydrooxepines for epidithiodiketopiperazines with two newly formed C–C bonds and one C–O bond.

Publisher URL: http://dx.doi.org/10.1021/acs.joc.7b00879

DOI: 10.1021/acs.joc.7b00879

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