Organic Letters
Organic Letters
5 years ago

Combined Effect of the Picoloyl Protecting Group and Triflic Acid in Sialylation

Combined Effect of the Picoloyl Protecting Group and Triflic Acid in Sialylation
Scott A. Geringer, Samira Escopy, Cristina De Meo
The stereoselective synthesis of sialosides is still one of the major challenges in carbohydrate chemistry. The synthesis and glycosidation of novel sialyl donors bearing a picoloyl substituent at C-4 are reported. High stereoselectivities and faster reactions were observed in the presence of an excess of triflic acid. The acid excess does not have the same effect on conventional sialyl donors, which suggests a possible synergistic effect of the picoloyl substituent and the triflic acid.

Publisher URL: http://dx.doi.org/10.1021/acs.orglett.7b00976

DOI: 10.1021/acs.orglett.7b00976

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