Journal of Organic Chemistry
Journal of Organic Chemistry
5 years ago

Synthesis of 6-Phosphorylated Phenanthridines by Mn(II)-Promoted Tandem Reactions of 2-Biaryl Isothiocyanates with Phosphine Oxides

Synthesis of 6-Phosphorylated Phenanthridines by Mn(II)-Promoted Tandem Reactions of 2-Biaryl Isothiocyanates with Phosphine Oxides
Wei-Si Guo, Jian Hou, Qian Dou, Li-Rong Wen, Ming Li
A novel Mn(II)-promoted tandem phosphorylation/cyclization reaction of 2-biaryl isothiocyanates with phosphine oxides is described. This is the first general method to synthesize 6-phosporylated phenanthridines from 2-biaryl isothiocyanates. The approach is featured by oxidant-free, low loading of P-reagent, easy operation, and high functional group tolerance.

Publisher URL: http://dx.doi.org/10.1021/acs.joc.7b00907

DOI: 10.1021/acs.joc.7b00907

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