Organic Letters
Organic Letters
5 years ago

Sequential Catalysis of Phosphine Oxide for Stereoselective Synthesis of Stereopentads

Sequential Catalysis of Phosphine Oxide for Stereoselective Synthesis of Stereopentads
Makoto Nakajima, Masaharu Sugiura, Kosuke Kai, Shunsuke Kotani
An efficient method for accessing enantiomerically pure stereopentads via a catalytic asymmetric sequential aldol reaction has been developed for the first time. The enantioselective sequential aldol reaction produces a wide range of chiral stereopentad precursors in good yields with excellent enantioselectivities. The key to success is the use of the sequential catalytic system involving a chiral phosphine oxide catalyst and trichlorosilyl triflate.

Publisher URL: http://dx.doi.org/10.1021/acs.orglett.7b01719

DOI: 10.1021/acs.orglett.7b01719

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