3 years ago

Huntingtin Fibrils Poke Membranes

Huntingtin Fibrils Poke Membranes
Pedro Guedes-Dias, Erika L.F. Holzbaur

A hallmark of Huntington's disease is the presence of intracellular aggregates of mutant huntingtin, the pathological significance of which has long been debated. Using cryo-electron tomography, Bauerlein et al. reveal the fibrillary structure of huntingtin aggregates in situ and show that huntingtin fibrils interact with the endoplasmic reticulum, distorting its morphology and dynamics.

Publisher URL: http://www.cell.com/cell/fulltext/S0092-8674(17)31058-9

DOI: 10.1016/j.cell.2017.09.009

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