3 years ago

Asymmetric Synthesis of cis-3,4-Dihydrocoumarins via [4 + 2] Cycloadditions Catalyzed by Amidine Derivatives

Asymmetric Synthesis of cis-3,4-Dihydrocoumarins via [4 + 2] Cycloadditions Catalyzed by Amidine Derivatives
Xiang-Yu Li, Wei-Ping Deng, Xiaoyan Luo, Jing-Hai Jin, John S. Fossey
A highly efficient chiral amidine derivative-catalyzed tandem Michael addition/lactonization of carboxylic acids and o-quinone methides (o-QMs) has been developed that enables the asymmetric synthesis of cis-3,4-dihydrocoumarins bearing contiguous tertiary stereogenic centers in high yields with excellent stereoselectivities.

Publisher URL: http://dx.doi.org/10.1021/acs.joc.7b00367

DOI: 10.1021/acs.joc.7b00367

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