Gold-Catalyzed Oxidation Terminal Alkyne: An Approach to Synthesize Substituted Dihydronaphthalen-2(1H)-ones and Phenanthrenols

4 years ago

Gold-Catalyzed Oxidation Terminal Alkyne: An Approach to Synthesize Substituted Dihydronaphthalen-2(1H)-ones and Phenanthrenols

Fang Yang, Kegong Ji, Bin Xu, Jin-Ming Gao, Hui-Bo Ling, Zi-Sheng Chen

A facile gold-catalyzed oxidation terminal alkynes to synthesize substituted dihydronaphthalen-2(1H)-ones 3 and phenanthrenols 5 was realized. Various useful structures and drug precursors were generated in up to 99% yield under mild condition and low catalyst loading.

Publisher URL: http://dx.doi.org/10.1021/acs.joc.7b01244

DOI: 10.1021/acs.joc.7b01244

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