Antimicrobial Agents and Chemotherapy
Antimicrobial Agents and Chemotherapy
5 years ago

High-Dose Ampicillin-Sulbactam Combinations Combat Polymyxin-Resistant Acinetobacter baumannii in a Hollow-Fiber Infection Model.

Nation RL, Tsuji BT, Tao X, Li J, Smith NM, Bulitta JB, Bulman ZP, Thamlikitkul V, Shin BS, Lenhard JR
Acinetobacter baumannii is emerging with resistance to polymyxins. In 24-h time-kill experiments, high-dose ampicillin-sulbactam in combination with meropenem and polymyxin B achieved additivity or synergy against 108 CFU/ml of two clinical A. baumannii isolates resistant to all three drugs (maximum reductions, 1.6 and 3.1 logs). In a 14-day hollow-fiber infection model, high-dose ampicillin-sulbactam (8/4 g every 8 h, respectively) in combination with meropenem (2 g every 8 h) and polymyxin B (1.43 mg/kg of body weight every 12 h with loading dose) resulted in rapid (96 h) eradication of A. baumannii.

Publisher URL: https://www.ncbi.nlm.nih.gov/pubmed/28052852

DOI: PubMed:28052852

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