Synthesis of 2,3-Benzodiazepines via Rh(III)-Catalyzed C–H Functionalization of N-Boc Hydrazones with Diazoketoesters

5 years ago

Synthesis of 2,3-Benzodiazepines via Rh(III)-Catalyzed C–H Functionalization of N-Boc Hydrazones with Diazoketoesters

Shan Guo, Shanke Zha, Lili Wang, Jie Wang, Jin Zhu

An efficient Rh(III)-catalyzed C–H activation protocol has been developed for the synthesis of 2,3-benzodiazepines with use of N-Boc hydrazones and diazoketoesters as substrates. The reaction features retention of the C═N and N–N bonds and selective cleavage of the N-Boc moiety.

Publisher URL: http://dx.doi.org/10.1021/acs.orglett.7b01642

DOI: 10.1021/acs.orglett.7b01642

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